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. 2021 Jan 18;7:14. doi: 10.1038/s41420-021-00403-5

Fig. 5. MLXIPL, as a potential biomarker, is correlated with a poor survival rate of HCC patients.

Fig. 5

A A violin plot revealed the mRNA level of MLXIPL in HCC clusters comparing to hepatocyte clusters. B, C Quantitative real-time PCR and western blotting analysis were performed to detect MLXIPL protein expression in six patients of HCC and para-tumor tissues used in single-cell sequence. ns P > 0.05; *P < 0.05; **P < 0.01. D PCR analysis were performed to detect MLXIPL mRNA expression in 68 patients of HCC and para-tumor tissues used in single-cell sequence. ***P < 0.001. E, F Representative immunohistochemistry pictures and IHC score of the MLXIPL protein expression. *P < 0.05. G, H Kaplan–Meier survival curve based on different expression levels of MLXIPL. J MLXIPL expression was significantly increased in HCC cells compared to L02 cells in mRNA level. ***P < 0.001. I MLXIPL protein was relatively overexpressed in HCC cells compared to L02 cells in protein level.