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. 2021 Jan 18;12:426. doi: 10.1038/s41467-020-20677-0

Fig. 1. POMC is expressed by the peripheral sensory neurons in healthy mice and humans.

Fig. 1

a Pomc gene expression (18srRNA normalized) quantified in lumbar DRG, sciatic nerves (SN) and footpads of healthy C57Bl/6 mice (n = 5 mice, 2 replicates from each mouse; one-way ANOVA followed by Tukey’s post-hoc test; ***p < 0.0001) b Expression of POMC protein (Rb anti-POMC antibody) and its colocalization with Tuj-1+ neurons in mouse lumbar DRG and SN (n = 6 mice, 4–6 sections per tissue from each mouse) and, schematic showing expression and axonal transport of POMC in the PNS. c Typical examples and d quantitative analysis of the distribution of neuronal-subtypes expressing POMC (Gt anti-POMC antibody) via co-immunolabeling with neuronal markers protein in lumbar DRG of healthy mice (n = 6, 4–10 DRG sections from each mouse) and healthy humans (n = 6 subjects, 4–10 DRG sections from each human subject). For all panels, data represent mean ± SEM; with 95% C.I. Circles represent individual data points. Scale = 50 μm. Source data are provided as a Source Data file.