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. 2021 Jan 18;12:426. doi: 10.1038/s41467-020-20677-0

Fig. 3. MOR is downregulated in the PNS of mice with experimental diabetes.

Fig. 3

a Oprm1 gene expression (18srRNA normalized) compared in lumbar DRG of control and 12 weeks diabetic mice (n = 5–6 mice/group, 2 replicates from each mouse; two-tailed t-test; n.s. = non-significant, p = 0.4) b Representative blot and densitometric quantification of MOR protein (∼55 KDa band normalized to actin) in total lysates of lumbar DRG (n = 9 mice/group; two-tailed t-test; **p = 0.002). c Typical examples and quantitative analysis showing MOR protein expression in Tuj-1+ neuronal cells in the lumbar DRG of control and diabetic mice (n = 6 mice/group; 8–10 DRG sections from each mouse; two-tailed t-test; ***p < 0.0001). For all panels, female mice data are shown; data represent mean ± SEM; with 95% C.I. Circles represent individual data points. Scale = 20 μm. Source data are provided as a Source Data file.