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. 2021 Jan 18;12:426. doi: 10.1038/s41467-020-20677-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Gait parameters analyzed using Catwalk system in naïve control and diabetic mice: a before and c after intraplantar PKC inhibitor injection, (Gö6983, 20 μM, 45 min) For panels (a) and (c), shown as dot plot with median; two-tailed t-test. Naïve control, n = 10, and Diabetic, n = 12; 5–6 readings per mouse. Circles represent individual data points. Orange circle: control, teal circle: diabetic mice. Gait parameters analyzed in diabetic mice overexpressing AAV-1/2 constructs in the right hindlimb: b before and d after intraplantar PKC inhibitor injection. Data expressed as a ratio of left hindpaw/right hindpaw. For panel (b), n = 10/cohort, 1–3 readings per mouse; one-way ANOVA with Dunnett’s post-hoc test. For panel (d), D + GFP, n = 9; D + MOR, n = 10; D + POMC, n = 10; D + POMC-MOR, n = 10; 1–4 readings per mouse. For panel (d), *represents significant difference compared to D + GFP cohort. For panels (b) and (d), data represent mean ± SEM; one-way ANOVA with Dunnett’s post-hoc test. Cyan bar: D + GFP, green bar: D + MOR, blue bar: D + POMC, red bar: D + POMC-MOR. For all panels, female mice data are shown; *p < 0.05, **p < 0.01, ***p < 0.001 with 95% C.I. Source data are provided as a Source Data file.