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. 2021 Jan 18;12:426. doi: 10.1038/s41467-020-20677-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a Typical examples and quantitative analysis showing expression of: b POMC and c MOR proteins in Tuj-1+ sciatic nerve sections of human subjects, stained using specific antibodies (non-diabetic healthy control, n = 11; type-1 diabetic patients, n = 4 subjects and type-2 diabetic, n = 11). For panels (b) and (c), data represent dot plot with median; 5–7 sections from each subject; one-way ANOVA followed by Dunnett’s post-hoc test; ***p < 0.0001 with 95% C.I. Each circle represents individual data point. Orange circle: non-diabetic, teal circle: type-1 diabetic and maroon circle: type-2 diabetic patient data. Scale = 50 μm. Source data are provided as a Source Data file.