Table 4.
Patient and treatment characteristics by AE grade for acute toxicities
| Grade 1-2 n = 65 | Grade 3 n = 7 | P value | |
|---|---|---|---|
| Age at reirradiation (years), median (range) | 63 (31-91) | 62 (39-80) | .61 |
| BMI (kg/m2) at reirradiation | |||
| <30 | 43 | 5 (10.4%) | 1.00 |
| >30 | 20 | 2 (22.2%) | |
| NR/NA | 2 | 0 (0%) | |
| Smoking history | |||
| Yes | 26 | 3 (10.3%) | 1.00 |
| No | 34 | 4 (10.5%) | |
| NR/NA | 5 | 0 (0%) | |
| Treatment modality at reirradiation | |||
| Photons | 48 | 4 (7.7%) | .39 |
| Protons | 17 | 3 (15.0%) | |
| Reirradiation fields | |||
| Unilateral breast/chest wall +/- nodes | 39 | 4 (9.3%) | .05 |
| Bilateral breast/chest wall +/- nodes | 6 | 3 (33.3%) | |
| Partial breast | 1 | 0 (0%) | |
| Regional nodes only | 19 | 0 (0%) | |
| Reirradiation to regional nodes | |||
| Yes | 47 | 5 (9.6%) | 1.00 |
| No | 18 | 2 (10.0%) | |
| Gross disease present at the time of reirradiation | |||
| Yes | 29 | 5 (14.7%) | .24 |
| No | 36 | 2 (5.3%) | |
| Concurrent capecitabine at reirradiation | |||
| Yes | 13 | 4 (23.5%) | .05 |
| No | 52 | 3 (5.5%) | |
| Concurrent hyperthermia at reirradiation | |||
| Yes | 13 | 2 (13.3%) | .63 |
| No | 52 | 5 (8.8%) | |
| bid treatment at reirradiation | |||
| Yes | 3 | 1 (25.0%) | .34 |
| No | 62 | 6 (8.8%) | |
| Prior RT dose including boost (Gy), median (IQR) | 60 (50-60.4) | 50 (38.5-60.0) | .14 |
| Reirradiation dose including boost (Gy), median (IQR) | 45 (40-50) | 50 (45-50.4) | .09 |
| Use of boost at reirradiation | |||
| Yes | 7 | 1 (12.5%) | .58 |
| No | 58 | 6 (9.4%) | |
| Cumulative RT dose including boost (Gy2), median (IQR) | 103.4 (94.79-109.1) | 110 (100-114) | .21 |
| Time between RT courses (months), median (IQR) | 76 (30-141) | 51 (11-61) | .11 |
| Degree of RT overlap | |||
| Full overlap | 56 | 7 (11.1%) | .58 |
| Partial overlap | 9 | 0 (0%) |
Abbreviations: AE = adverse events; BMI = body mass index; IQR = interquartile range; NA = not applicable; NR = not reported; RT = radiation therapy.
P values less than .05 have been bolded to highlight significance.