Figure 1.

Accelerated re-epithelialization and reduced contraction in wounds treated with MSTCs. (a) Representative images of control and MSTC-treated wounds shown at time 0 (immediately after treatment, MSTCs can be seen in the wound bed as short, white, rod-like structures), one week and two weeks after wounding. Wound margins were tattooed with black ink. (b) Change in total wound area shows reduced wound contraction in MSTC-treated wounds by week 2. (c) Wound areas with visible epithelialization at week 2 were quantified and compared. Pie charts show proportion of wounds that were fully vs. incompletely re-epithelialized at week 2. Graph shows overall extent of re-epithelialization. 10 out of 12 MSTC-treated wounds were completely re-epithelialized, for an overall average of 99% re-epithelialization, whereas none of the 8 control wounds had complete re-epithelialization (average re-epithelialization of 56% in controls). *p < 0.05.