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. 2021 Jan 18;11:1688. doi: 10.1038/s41598-021-81179-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Attenuation of inflammatory response in wounds treated with MSTCs. (a) H&E staining showing inflammatory infiltrate in control wounds, with high densities of neutrophils and macrophages (identifiable by their characteristic polymorphic and euchromatic nuclei, respectively). Scale bar = 25 μm. (b) Whole-biopsy view of CD45 staining (red) in a control wound at 1 week. Scale bar = 2.5 mm. (c) CD45 staining of a control wound at 2 weeks. Scale bar = 2.5 mm. (d) High-power view of CD45 staining in a control wound at 2 weeks. Scale bar = 50 μm. (e) Whole-biopsy view of CD45 staining of an MSTC-treated wound 1 week. Scale bar = 2.5 mm. (f) CD45 staining of an MSTC-treated wound at 2 weeks. Scale bar = 2.5 mm. (g) High-power view of CD45 staining in an MSTC-treated wound at 2 weeks. Scale bar = 50 μm. (h) Quantitative evaluation of CD45+ areas in MSTC-treated vs. control wounds. Density of CD45+ leukocytes was significantly lower in MSTC-treated wounds compared to controls at both time points. ****p $\leq$ 0.0001.