Table 2.
Neurological outcomes in the HDP and non-HDP groups in univariate and multivariate analyses.
| Variables | HDP | Non-HDP | Crude OR (95% CI) | Adjusted OR (95% CI) | ||
|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | ||||
| Short-term outcomes | (n = 4,584) | (n = 4,584) | ||||
| IVH (grade III or IV) | 108/4.565 (2.4%) | 157/4,565 (3.4%) | 0.68 (0.53–0.87) | 0.47 (0.35–0.63) | 0.76 (0.58–1.00) | 0.82 (0.61–1.09) |
| PVL | 111/4,567 (2.4%) | 181/4,568 (4.0%) | 0.60 (0.48–0.77) | 0.59 (0.45–0.78) | 0.63 (0.48–0.81) | 0.69 (0.52–0.90) |
| Neonatal seizures | 63/4,577 (1.4%) | 98/4,579 (2.1%) | 0.64 (0.46–0.88) | 0.40 (0.28–0.57) | 0.59 (0.42–0.84) | 0.61 (0.42–0.88) |
| In-hospital death | 181/4,583 (3.9%) | 140/4,582 (3.1%) | 1.31 (1.04–1.63) | 0.61 (0.47–0.80) | 1.34 (1.04–1.72) | 1.11 (0.85–1.44) |
| Medium-term outcomes | (n = 2,114) | (n = 1,969) | ||||
| Cerebral palsy | 112/1,845 (6.1%) | 120/1,737 (6.9%) | 0.87 (0.67–1.14) | 0.70 (0.52–0.95) | 0.89 (0.67–1.19) | 0.92 (0.68–1.25) |
| DQ of < 70 | 216/1,344 (16.1%) | 167/1,264 (13.2%) | 1.26 (1.01–1.57) | 0.93 (0.72–1.20) | 1.34 (1.05–1.71) | 1.18 (0.91–1.52) |
| Total death by 3 years of age | 192/2,114 (9.1%) | 159/1,969(8.1%) | 1.14 (0.91–1.42) | 0.59 (0.45–0.78) | 1.21 (0.95–1.54) | 1.02 (0.79–1.31) |
Data are given as n (%). Adjusted ORs were evaluated by multivariate analyses (models 1, 2, and 3). Bold text indicates a significant association.
Model 1: diabetes mellitus or gestational diabetes mellitus, histological chorioamnionitis, administration of antenatal corticosteroid, mode of delivery, gender, and birth weight were included in the logistic regression model.
Model 2: diabetes mellitus or gestational diabetes mellitus, histological chorioamnionitis, administration of antenatal corticosteroid, mode of delivery, and gender were included in the logistic regression model.
Model 3: diabetes mellitus or gestational diabetes mellitus, histological chorioamnionitis, administration of antenatal corticosteroid, mode of delivery, gender, and SGA were included in the logistic regression model.
HDP, hypertensive disorders of pregnancy; IVH, intraventricular haemorrhage; PVL, periventricular leukomalacia; DQ, developmental quotient; OR, odds ratio; CI, confidence interval; SGA, small for gestational age.