Table 4.
Differentially expressed genes (DEGs) between GATA3-mutant versus normal and GATA3-non-mutant versus normal and GATA3-mutant versus non-mutant tissues according to the TCGA data.
| Gene name | Fold change | FDR | Gene name | Fold change | FDR | |
|---|---|---|---|---|---|---|
| GATA3 mutant versus normal | All patients: 4816 (2476 up-regulated and 2340 down-regulated genes) | ER-Positive patients: 4522 (2143 up-regulated and 2379 down-regulated genes) | ||||
| Up-regulated DEGs | MUC2 | 10.43879 | 3.33E−24 | MUC2 | 8.329625376 | 2.62 E−18 |
| CGA | 9.492646 | 3.97 E−24 | CHRNA9 | 7.628457572 | 7.85 E−21 | |
| CHRNA9 | 9.389171 | 1.25E−26 | CGA | 7.332730083 | 1.31E−18 | |
| CPLX2 | 8.522081 | 5.63E−19 | PCSK1 | 6.922966106 | 1.79E−19 | |
| CST4 | 8.506592 | 2.09E−43 | TRH | 6.85432771 | 8.50E−19 | |
| Down-regulated DEGs | MYH2 | − 11.8785 | 1.83E−45 | MYH2 | − 11.8811779 | 6.71E−38 |
| CKM | − 11.8163 | 3.02E−44 | NRAP | − 9.667105996 | 8.76E−31 | |
| NRAP | − 9.63614 | 4.01E−36 | TNNC2 | − 8.329242401 | 9.99E−42 | |
| TNNC2 | − 8.32733 | 3.04E−51 | TCAP | − 8.199816299 | 5.68E−32 | |
| ACTA1 | − 8.21929 | 4.09E−35 | ACTA1 | − 8.118831848 | 4.32E−30 | |
| GATA3 non-mutant versus normal | All patients: 4308 (2593 up-regulated and 1715 down-regulated genes) | ER-Positive patients: 4066 (2055 up-regulated and 2011 down-regulated genes) | ||||
| Up-regulated DEGs | S100A7A | 8.467232 | 9.82E−22 | CST5 | 6.658392275 | 1.67E−18 |
| CSAG1 | 8.423582 | 3.50E−26 | S100A7A | 6.546948974 | 1.96E−16 | |
| CST5 | 8.403968 | 2.03E−22 | CGA | 6.525469762 | 1.16E−17 | |
| CGA | 8.399469 | 2.10E−22 | CARTPT | 6.349247937 | 1.00E−10 | |
| MAGEA12 | 8.173768 | 5.55E−22 | CST4 | 6.32237147 | 7.11E−34 | |
| Down-regulated DEGs | MYH2 | − 8.18882 | 1.49E−120 | MYH2 | − 7.688190533 | 6.83E−80 |
| CKM | − 7.80643 | 4.34E−112 | PYGM | − 6.809240454 | 7.50E−145 | |
| PYGM | − 7.07911 | 1.61E−215 | ACTA1 | − 6.782578399 | 4.19E−79 | |
| NRAP | − 6.89436 | 1.09E−95 | ATP2A1 | − 6.539245722 | 2.40E−113 | |
| ATP2A1 | − 6.75453 | 8.90E−171 | NRAP | − 6.423415223 | 1.04E−63 | |
| GATA3 mutant versus non-mutant | All patients: 907 (169 up-regulated and 738 down-regulated genes) | ER-Positive patients: 480 (103 up-regulated and 377 down-regulated genes) | ||||
| Up-regulated DEGs | ALDOB | 3.731806 | 9.25E−87 | ALDOB | 4.193275263 | 1.63E−90 |
| AMY2A | 3.414509 | 9.25E−87 | AMY2A | 3.62447513 | 3.97E−73 | |
| C8orf34 | 3.308972 | 2.16E−59 | C8orf34 | 3.23103563 | 1.77E−44 | |
| ZPLD1 | 2.907425 | 4.75E−32 | ZPLD1 | 2.950533096 | 9.72E−27 | |
| LOC284749 | 2.889682 | 1.42E−31 | ||||
| Down-regulated DEGs | SMR3B | − 9.48864 | 3.11E−16 | CSN1S1 | − 8.610397883 | 1.76E−14 |
| CSN1S1 | − 8.13224 | 3.62E−15 | MYOC | − 5.400766258 | 8.60E−13 | |
| CSN3 | − 7.72831 | 1.09E−13 | MSLN | − 4.537413853 | 3.42E−14 | |
| C4orf7 | − 6.20695 | 1.00E−14 | DMBT1 | − 4.476329021 | 4.97E−12 | |
| FABP7 | − 6.20416 | 7.96E−16 | MYH2 | − 4.192987371 | 2.92E−10 | |
| SMR3B | − 4.029963607 | 1.15E−07 | ||||