Table 1.
Comparison of the gene expression in the kidney from WKY rats, SHR, and SHRSP by DNA microarray analysis
| WKY rats | SHR | SHRSP | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene name | Description | Normalized | Raw | Fold change | Normalized | Raw | Fold change | Normalized | Raw | Fold change |
| SHR/WKY rats >2.0 in renal cortex | ||||||||||
| Bcl6 | B-cell CLL/lymphoma 6 | 0.87 | 95.6 | 1 | 2.73 | 253.5 | 3.13 | 2.80 | 207.2 | 3.21 |
| Dnajb9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.21 | 18.9 | 1 | 0.47 | 37.8 | 2.25 | 0.49 | 34.4 | 1.58 |
| Fkbp5 | FK506 binding protein 5 | 0.79 | 73.1 | 1 | 4.00 | 309.0 | 5.09 | 1.09 | 84.8 | 1.30 |
| Gmfb | Glia maturation factor, beta | 0.18 | 16.4 | 1 | 0.38 | 29.2 | 2.14 | 0.32 | 22.7 | 1.13 |
| Gucy1a2 | Guanylate cyclase 1, soluble, alpha 2 | 0.14 | 20.0 | 1 | 0.331 | 25.4 | 2.46 | 0.20 | 13.2 | 1.51 |
| Lztfl1 | Leucine zipper transcription factor-like 1 | 0.11 | 12.2 | 1 | 0.348 | 26.6 | 3.13 | 0.13 | 10.4 | 1.20 |
| Nr1d1 | Nuclear receptor subfamily 1, group D, member 1 | 0.07 | 6.13 | 1 | 0.443 | 35.3 | 6.71 | 0.43 | 29.9 | 6.48 |
| Pdia4 | Protein disulfide isomerase family A, member 4 | 0.73 | 65.5 | 1 | 1.6 | 122.4 | 2.18 | 0.96 | 64.3 | 1.31 |
| Ppargc1b | Peroxisome proliferator-activated receptor gamma, coactivator 1 beta | 1.05 | 97.0 | 1 | 2.80 | 214.2 | 2.66 | 1.74 | 118.9 | 1.65 |
| Ppat | Phosphoribosyl pyrophosphate amidotransferase | 0.33 | 30.3 | 1 | 0.73 | 55.9 | 2.19 | 0.81 | 54.4 | 2.44 |
| Slc39a11 | Solute carrier family 39 (metal ion transporter), member 11 | 0.16 | 14.2 | 1 | 0.34 | 25.7 | 2.15 | 0.270 | 18.3 | 1.71 |
| Slc43a1 | Solute carrier family 43, member 1 | 0.12 | 12.7 | 1 | 0.39 | 31.1 | 3.32 | 0.24 | 16.4 | 1.21 |
| Tef | Thyrotrophic embryonic factor | 0.20 | 18.1 | 1 | 1.03 | 82.8 | 5.27 | 0.53 | 37.5 | 2.57 |
| Tesk2 | Testis-specific kinase 2 | 0.17 | 15.7 | 1 | 0.39 | 29.8 | 2.27 | 0.12 | 8.91 | 0.71 |
| Tgfb2 | Transforming growth factor, beta 2 | 0.09 | 10.5 | 1 | 0.34 | 26.2 | 3.59 | 0.07 | 4.67 | 1.28 |
| Tsku | Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis) | 4.68 | 429.0 | 1 | 10.2 | 791.9 | 2.17 | 6.02 | 409.2 | 1.28 |
| Zmym6 | Zinc finger, MYM-type 6 (Zmym6), mRNA | 0.16 | 14.4 | 1 | 0.32 | 24.9 | 2.03 | 0.19 | 13.1 | 0.79 |
| SHR/WKY rats <0.5 in renal cortex | ||||||||||
| Anapc13 | Anaphase promoting complex subunit 13 | 0.60 | 58.8 | 1 | 0.22 | 22.3 | 0.37 | 0.42 | 30.9 | 1.17 |
| Fxr1 | Fragile X mental retardation, autosomal homolog 1 | 0.59 | 55.1 | 1 | 0.22 | 20.6 | 0.38 | 0.29 | 21.6 | 0.49 |
| Hnrrnpa3 | Heterogeneous nuclear ribonucleoprotein A3 | 0.64 | 73.8 | 1 | 0.31 | 28.1 | 0.49 | 0.22 | 19.0 | 0.35 |
| Npm1 | Nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 1.98 | 238.0 | 1 | 0.96 | 87.4 | 0.49 | 1.03 | 73.8 | 0.50 |
| Nptx1 | Neuronal pentraxin 1 | 0.49 | 43.6 | 1 | 0.051 | 3.87 | 0.10 | 0.08 | 5.08 | 0.18 |
| Plagl1 | Pleiomorphic adenoma gene-like 1 | 0.53 | 47.8 | 1 | 0.26 | 20.5 | 0.50 | 0.20 | 13.3 | 0.40 |
| Plbd1 | Phospholipase B domain containing 1 | 0.32 | 29.8 | 1 | 0.14 | 14.1 | 0.44 | 0.12 | 9.17 | 0.38 |
| Tbl1x | Transducin (beta)-like 1 X-linked | 0.64 | 66.7 | 1 | 0.30 | 36.1 | 0.48 | 0.32 | 22.0 | 0.50 |
| Trim46 | Tripartite motif-containing 46 | 0.42 | 38.7 | 1 | 0.10 | 7.85 | 0.23 | 0.20 | 14.6 | 0.48 |
| Tfrc | Transferrin receptor | 0.81 | 83.6 | 1 | 0.30 | 28.1 | 0.37 | 0.79 | 52.8 | 2.14 |
| SHR/WKY rats >2.0 in renal medulla | ||||||||||
| Dnajb9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.21 | 18.4 | 1 | 0.46 | 37.29 | 2.20 | 0.37 | 31.7 | 1.60 |
| Fkbp5 | FK506 binding protein 5 | 0.59 | 54.2 | 1 | 2.50 | 206.2 | 4.24 | 1.20 | 106.0 | 1.90 |
| Nr1d1 | Nuclear receptor subfamily 1, group D, member 1 | 0.21 | 18.3 | 1 | 0.65 | 55.0 | 3.13 | 0.44 | 38.6 | 2.10 |
| Nrip3 | Nuclear receptor interacting protein 3 | 0.17 | 22.7 | 1 | 0.44 | 37.4 | 2.57 | 0.56 | 57.0 | 0.97 |
| Ppargc1b | Peroxisome proliferator-activated receptor gamma, coactivator 1 beta | 1.13 | 102.2 | 1 | 2.71 | 225.8 | 2.40 | 1.63 | 138.0 | 1.44 |
| Pwp2 | PWP2 periodic tryptophan protein homolog (yeast) | 0.61 | 52.7 | 1 | 1.26 | 105.5 | 2.08 | 0.17 | 17.8 | 0.80 |
| Slc38a2 | Solute carrier family 38, member 2 | 1.21 | 104.6 | 1 | 2.54 | 224.6 | 2.11 | 1.55 | 133.2 | 1.33 |
| Tef | Thyrotrophic embryonic factor | 0.27 | 27.8 | 1 | 0.83 | 68.0 | 3.01 | 0.73 | 65.1 | 2.52 |
| Tnfrsf21 | Tumor necrosis factor receptor superfamily, member 21 | 0.32 | 31.4 | 1 | 0.84 | 68.8 | 2.63 | 8.26 | 704.2 | 1.37 |
| Tsku | Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis) | 3.38 | 306.1 | 1 | 7.66 | 638.8 | 2.27 | 3.33 | 287.3 | 0.99 |
| SHR/WKY rats <0.5 in renal medulla | ||||||||||
| Tfrc | Transferrin receptor | 0.80 | 69.1 | 1 | 0.35 | 35.7 | 0.44 | 0.63 | 53.4 | 2.76 |