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. Author manuscript; available in PMC: 2021 Jan 18.
Published in final edited form as: Toxicol In Vitro. 2019 Mar 28;58:230–238. doi: 10.1016/j.tiv.2019.03.022

FIG. 5.

FIG. 5.

(A) Percent difference from 37°C control of T4 (1.0 μM) uptake in cryopreserved rat hepatocyte suspensions treated with varying concentrations of the serum protein transthyretin. Data represent the linear rate of T4 hepatic uptake (pmoles/106 cells/sec) determined from individual timelines conducted in triplicate within a single experiment. Error bars represent ± SD, asterisks denote statistically significant differences versus the temperature control regression slopes (*p<0.05). (B) Percent difference from 37°C control of free T4 (1.0 μM) levels determined by 10kDa filtration of running buffer solutions with varying transthyretin concentration levels (no hepatocytes). Error bars represent ± SD, asterisks denote statistically significant differences versus the temperature control (*p<0.05).