Table 1.
Summary of experimental design with pooled cryopreserved rat hepatocyte lots.
| Experimenta | Number of individual experiments by lot | Number of individual experiments | Number of samples for timeline analysis | TTR treatment % control | |||
|---|---|---|---|---|---|---|---|
| SNQ (donors = 24) | CZX (donors = 6) | ZHN (donors = 45) | |||||
| Control | No TTR | 2 | 2 | 4 | 48 | ||
| TTR | 1 | 1 | 1 | 3 | 36 | ||
| PFOA (10 μM) | No TTR | 1 | 1 | 12 | |||
| TTR | 1 | 1 | 2 | 24 | 206–298 | ||
| PFOS (10 μM) | No TTR | 1 | 1 | 12 | |||
| TTR | 1 | 1 | 12 | 226 | |||
| Octanoic Acid (10 μM) | No TTR | ||||||
| TTR | 1 | 1 | 12 | 154 | |||
| Cyclosporin A (10 μM) | No TTR | 1 | 1 | 12 | |||
| TTR | 1 | 1 | 12 | 53 | |||
| Number of experiments | 7 | 3 | 5 | 15 | |||
| Number of samples for timeline analysis | 84 | 36 | 60 | 180 | |||