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. 2021 Jan 14;14:435–444. doi: 10.2147/OTT.S287722

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© 2021 Han et al.

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Inhibition of HSDL2 suppressed PC cell proliferation and cell cycle. (A) HSDL2 expression level in si-HSDL2#1, si-HSDL2#2 and si-HSDL2#3 was exhibited by Western blot, while β-Actin was used as a loading control in Bxpc-3 and Panc-1 cells. (B) The proliferative capacity of PC cells was obviously reduced after silencing of HSDL2 in MTT assay. (C) The colony-forming ability of PC cells was attenuated by HSDL2 silencing. (D) The effect of HSDL2 expression on PC cell proliferation was measured by EdU assay. (E) Compared with the control group, knockdown HSDL2 regulated cell cycle protein (CDK1, cyclinB1, cyclinD1) in Bxpc-3 and Panc-1 cells by Western blot. *P<0.05, **P<0.01.