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. 2021 Jan 14;14:435–444. doi: 10.2147/OTT.S287722

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© 2021 Han et al.

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Si-HSDL2 altered lipid metabolism of PC. (A) GO analysis indicated fatty acid metabolic process as the main part involved GO term in relation to HSDL2 expression. (B) HSDL2 was significantly associated with lipogenesis gene SREBF1 and ACC1. (C) Correlation between HSDL2 expression and phospholipid and triglyceride level was detected by phospholipid and triglyceride kit assay. (D) HSDL2 silencing decreased the contents of lipid production in Bxpc-3 and Panc-1 cells through BODIPY 493/503 staining. (E) Compared with the control group, HSDL2 gene silencing regulated lipogenesis genes (FASN, ACC1, ACSL1, SREBP1) in Bxpc-3 and Panc-1 cells by Western blot. **P<0.01.