Figure 2.

Levels of IFN‐γ secretion directly correlated with cell proliferation magnitude. Cells from 228 subjects at six time points (days 0, 8, 14, 28, 56 and 180) were stimulated with Schu‐S4. (a) After 4 days of stimulation, supernatants were harvested and used to measure IFN‐γ production using MSD technology. Symbols and error bars represent the geometric mean of the IFN‐γ levels (pg mL⁻¹) with 95% confidence interval. Peak, peak increase as defined by the maximum level of IFN‐γ increase among all the available measures on time points post‐vaccination. Data are representative of 32 independent experiments with one replicate. Correlation between IFN‐γ levels and cell proliferation magnitudes, for both vaccines, USAMRIID‐LVS (b) and DVC‐LVS (c). Trendlines (solid lines), the correlation coefficient R and P‐values are shown. P‐values of < 0.05 were considered statistically significant. Dashed lines represent 95% confidence intervals. Per‐Protocol Population.