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. Author manuscript; available in PMC: 2021 Feb 17.
Published in final edited form as: Risk Anal. 2020 Apr 29;41(2):303–311. doi: 10.1111/risa.13486

Table 2:

Expected detected-event free period (DEFP) required for 95% and 99% confidence about no circulation (CNCx%) and time of undetected circulation between the last paralytic case and die-out (TUCx%) in Borno and Yobe assuming perfect and imperfect surveillance (based on 1,000 iterations) for WPV1* (two scenarios) and WPV3.

Virus WPV1 (PIR = 1/200) WPV3 (PIR = 1/1000)
POE 100% 100%
Metric CNCx% TUCx% CNCx% TUCx%
x% 95% 99% 95% 99% 95% 99% 95% 99%
DEFP values assuming perfect AFP surveillance
Scenario 1 1.33 1.83 0.97 1.38 1.75 2.50 1.41 1.76
Scenario 2 1.58 1.92 0.98 1.34
DEFP values assuming less than perfect AFP surveillance, lower bound
Scenario 1 3.00 3.75 2.75 3.69 3.08 6.50 2.21 6.49
Scenario 2 3.42 3.75 3.35 3.72
DEFP values assuming less than perfect AFP surveillance, accessibility factor
Scenario 1 1.92 2.25 1.14 1.58 2.42 4.42 1.52 3.99
Scenario 2 2.08 2.50 1.11 1.69
DEFP values assuming less than perfect AFP surveillance, upper bound
Scenario 1 1.75 2.08 1.07 1.58 2.25 3.42 1.48 3.18
Scenario 2 2.00 2.33 1.05 1.46
*

Scenario 1 assumes sufficient indirect vaccination introductions into the isolated subpopulations to eliminate undetected WPV1 transmission after the outbreak detected in 2016; Scenario 2 assumes insufficient indirect vaccination introductions into isolated subpopulations to eliminate undetected WPV1 transmission through the end of 2019.

Abbreviations: AFP, acute flaccid paralysis; CNCx%, DEFP at which the confidence about no circulation exceeds x%; DEFP, detected-event-free period; PIR, paralysis-to-infection ratio; POE, probability of eradication; TUCx%, the xth percentile of the distribution of the times of undetected circulation after the last detected-event (for those iterations in which extinction occurs); WPV(1,3), wild poliovirus (serotypes 1,3).