Table 1.
Group | Neutrophils (mean × 103/µL ± SD)a | |
---|---|---|
Day 1 post-infection | Day 3 post-infection | |
Control | 0.95 ± 0.29 | 0.88 ± 0.1 |
Immunocompetent/exposed | 0.88 ± 0.19 | 0.94 ± 0.67 |
CTX-IPA | 0.01 ± 0.01*,# | 0.02 ± 0.01*,# |
HC-IPA | 1.43 ± 0.77 | 2.55 ± 1.68 |
Treatments were as follows: cyclophosphamide (250 mg/kg) intraperitoneally on the day before the 1st and 3rd challenges (CTX-IPA); hydrocortisone (62.5 mg/kg) subcutaneously every other day, from 5 days before infection (d-5) to the day after infection (d + 1)(HC-IPA);
Mice were infected intranasally with 50 μL (1 × 108conidia/mL) of A. fumigatus spore suspension. The groups of control received 50 μL of phosphate buffer saline (PBS). Blood samples were collected from four mice per group at the indicated days post-infection
aSD, standard deviation; *p < 0.05, compared with the control group. #p < 0.05, compared with the immunocompetent/exposed group