Table 3.
Effect of PTX on pulmonary fungal burden
| Group | Pulmonary fungal burden (mean log10 CFU/g ± SD)a | ||
|---|---|---|---|
| Day 1 post-infection | Day 3 post-infection | Day 5 post-infection | |
| Immunocompetent/exposed | 5.1 ± 0.43c | None | None |
| CTX-IPA | 6.18 ± 0.41c | 4.19 ± 0.35* | NDb |
| CTX-IPA + PTX | 5.61 ± 0.52 | 2.77 ± 1.06* | NDb |
| HC-IPA | 5.95 ± 0.65c | 3.27 ± 0.41 | 2.34 ± 0.24 |
| HC-IPA + PTX | 5.13 ± 1.30 | None | None |
Immunosuppressed mice, infected with A. fumigatus, were injected intraperitoneally with 20 mg/kg PTX daily for 5 days. Lung tissue samples from four mice per group were collected on days 1, 3, and 5 post-infection
aCFU, colony-forming unit; SD, standard deviation
bND, not detected
cp < 0.05 compared with the immunocompetent/exposed group
*p < 0.05, CTX-IPA group vs. CTX-IPA + PTX group