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. 2021 Jan 18;13:11. doi: 10.1186/s13148-020-00975-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Methylation pattern of invasive lobular breast cancer (ILBC) samples. Heatmaps show the methylation patterns of invasive lobular breast cancer (ILBC) samples in the Melbourne Collaborative Cohort Study (MCCS) across the ten most significant variably methylated regions (VMRs): a ISM1, b APC, c TMEM101, d ASCL2, e NKX6, f HIST3H2A, g HCG4P3, h HES5, i CELF2 j EFCAB4B. Annotation of CpGs by genomic position and location in the context of gene are marked on the maps. Annotation of samples by age at diagnosis and tumour characteristics are shown in the colour bars as indicated in the legend on the top-right. The methylation beta-value of the CpG positions shown in the heatmap is indicated in the colour key on the top-right corner