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. 2021 Jan 18;13:11. doi: 10.1186/s13148-020-00975-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Genomic distribution of the variably methylated regions (VMRs). Bar plots show the distribution of 2771 variably methylated regions (VMRs) identified within invasive lobular breast cancer (ILBC) samples in the Melbourne Collaborative Cohort Study (MCCS) a relative to CpG islands, shores (0–2 kb from island), shelves (2–4 kb from island) and open sea and b in relation to the gene. Different genomic locations are shown on the x-axis and the percentage of CpG positions related to the VMRs is shown on the y-axis. The distribution of the HM450K probes relative to each CpG context is also indicated. P-values (Chi-square test) assessing significant enrichment in a given category relative to the HM450K array composition are indicated (*P < 0.001)