Table 4.

Pooled hazard ratios for the association between methylation levels at the ten most VMRs and overall survival: meta-analysis of the MCCS and TCGA results

			Adjusted for age		Adjusted for age and stage
Gene*	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
APC	1.24 (1.07–1.44)	0.004	1.20 (1.04–1.39)	0.01	1.18 (1.02–1.36)	0.03
TMEM101	1.19 (1.00–1.42)	0.05	1.17 (0.99–1.39)	0.06	1.23 (1.02–1.48)	0.03
ISM1	1.38 (1.05–1.80)	0.02	1.09 (0.84–1.42)	0.50	1.03 (0.77–1.36)	0.83
ASCL2	1.19 (0.88–1.61)	0.24	0.99 (0.74–1.33)	0.96	1.08 (0.81–1.45)	0.57
HIST3H2A	1.30 (1.08–1.57)	0.004	1.15 (0.95–1.37)	0.14	1.09 (0.91–1.31)	0.33
NKX6	1.40 (1.13–1.74)	0.002	1.21 (0.98–1.50)	0.08	1.18 (0.95–1.46)	0.13
HCG4P3	1.45 (1.13–1.85)	0.003	1.30 (1.00–1.67)	0.04	1.37 (1.05–1.79)	0.02
HES5	1.15 (0.95–1.40)	0.15	1.12 (0.92–1.36)	0.25	1.13 (0.92–1.38)	0.23
CELF2	1.34 (1.13–1.60)	0.0006	1.18 (1.00–1.40)	0.05	1.21 (1.02–1.43)	0.02
EFCAB4B	1.12 (0.95–1.32)	0.17	1.05 (0.89–1.22)	0.57	1.05 (0.90–1.23)	0.49

*Gene: Gene associated with the variably methylated regions (VMRs), most of the VMRs were located in the promoter region of the genes, HR hazard ratio, CI confidence interval