Figure 3.

The effect of topical mGluR2/3 agonist LY354740 application on RLFs’ peak firing rates (A1, B1, C1), slopes (A2, B2, C2), and thresholds (A3, B3, C3). A, At the population level (n = 31), MGluR2/3 activation significantly increased the peak firing rates, steepened the slopes, and lowered the thresholds. Neurons were then assigned to two groups: those which had RLFs affected by topical mGluR2/3 agonist LY354740 (B; n = 20), and those in which mGluR2/3 activation did not have a clear effect (C; n = 11). Each neuron’s mean pre-drug and mean post-drug values are connected by gray lines; population data are summarized with boxplots (the plot presents Box–Cox transformed data); NS p > 0.05, **p < 0.001, ***p < 0.0001.