Figure 2.

A, Immunoblots of extracts of sciatic nerves from intact mice and from nerves cut and repaired one week earlier. IR to an antibody recognizing the product of APP produced by AEP cleavage, APP N585 (top), and full-length APP (bottom) are shown. B, Quantitative analysis of differences in expression of full-length APP (left) and APP N585 (right) between intact nerves and cut and repaired nerves, relative to β actin controls, are shown for a group of male and female mice as mean fold (±SEM) intensities. The horizontal dashed line at unity marks the amount of IR found in Intact mice. C, Time course of expression of APP N585 in cut and repaired sciatic nerves. The horizontal dashed line at unity marks the amount of IR found in AEP KO mice.