A, Effects of ES on recovery of direct muscle (M) response amplitude in AEP KO mice. Mean (±SEM) scaled M response amplitudes recorded from GAST (left) and TA (right) muscles four weeks after sciatic nerve transection and repair. Both AEP KO mice and WT mice were studied. Mice of each genotype either were treated at the time of nerve repair with 1 h of 20-Hz ES of the proximal nerve stump or left untreated. B, Effects of ES on BDNF-TrkB expression in WT and AEP KO mice. Immunoblots from sciatic nerves 7 d following nerve transection and repair were probed for two markers of BDNF-TrkB signaling: phosphorylation of the TrkB receptor at Y816 and phosphorylation of the downstream effector, AKT. IR to both is increased in ES mice relative to untreated (UT) controls in both WT and AEP KO animals. C, Effects of ES on AEP cleavage of APP and Tau. Immunoblots from animals used in panel C were probed with antibodies to AEP, full-length APP and Tau, and the AEP cleavage products of these two proteins, APP N585 and Tau N368. The solid arrow points to the greater amount of IR to inactive AEP in the ES mouse.