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. Author manuscript; available in PMC: 2021 Aug 18.
Published in final edited form as: Acc Chem Res. 2020 Jul 21;53(8):1593–1604. doi: 10.1021/acs.accounts.0c00292

Figure 6.

Figure 6.

Dinitroindolinyl caged glutamates - probes with exceptional quantum yields.

A. Structures of MDNI-Glu53, CNI-Glu54 and CDNI-Glu54. B. Comparison functional 2P-mapping on the grid (left) using MNI- and CDNI-Glu on the same dendrite54. C. Spectra of the CDNI and ChR2 (normalized). D. (i) Scheme for structural LTP using 2-color actuation55. (ii) Blue-light evoked dopamine concentration measured by amperometry. (iii) 2P-evoked glutamate current at a single spine. (iv) Outline of the timing combination of 2P uncaging and optogenetic release of dopamine. (v) Summary of the relationship between dopamine timing and structural LTP. Optimum effects of dopamine input were between 0.25–1.0 s. No LTP was seen at −1 s or > +2 s. B: Adapted with permission from ref. 54. Creative Commons License. D: Adapted with permission from ref. 55. Copyright (2014) AAAS.