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. Author manuscript; available in PMC: 2021 Aug 18.
Published in final edited form as: Acc Chem Res. 2020 Jul 21;53(8):1593–1604. doi: 10.1021/acs.accounts.0c00292

Figure 7.

Figure 7.

CDNI-GABA – two-photon uncaging of the major inhibitory transmitter.

A. Structure of CDNI-Glu57. B. Example of rapid, GABA-A selective 2P-evoked current57. C. 2P photolysis of CDNI-GABA mimics quantal release57. D. Functional mapping57 of neuronal GABA-A receptors (i) required a mode-locked laser (ii) vs (iii), and was reproducible (ii) & (iv). E. Axial resolution of 2P uncaging of CDNI-GABA was diffraction-limited57. F. 2P photolysis of CDNI-GABA on young neurons induces GABA synaptogenesis and spinogenesis in vitro (i) and in vivo (ii). G. Most photo-induced synapses were stable for longer than 25–30 min60. B-E Reproduced from ref. 57. Copyright (2010) GCRE-D. E,F: Reproduced with permission from ref. 60. Copyright (2016) AAAS.