Table 2.

Characteristic of T cells infiltrating into the injured brain in acute and chronic phases after

Author	Animal model	Acute phase (within 7 days)	Chronic phase (after 14 days)	Year
Stubbe et al. [7]	30 min MCAO	CD4+ T cells and Tregs elevating in the peri-infarct and infarct area with MHCII+ DCs and MHCII+ macrophages after ischemic stroke	More CD4+ and Tregs elevating in the ischemic hemisphere consistent with increasing MHCII+ microglia, DCs and macrophages in the injured brain after ischemic stroke	2013
Vindegaard et al. [89]	pMCAO	Only a few CD3+ T cells infiltrating into the brain, predominantly located to the meningeal areas or in close proximity to a vessel, in the vicinity of the infarct with a few macrophage/microglia infiltrating the infarct area	A high number of macrophage/microglia infiltrating the infarct area and increasing T cell numbers within the infarct core and the corpus callosum	2017
Xie et al. [90]	90 min MCAO	Activated/memory phenotype of T cells (either CD4+ or CD8+) infiltrating the ischemic hemisphere	Greater proportion of activated/memory T cells than the acute phase with CD25, a T cell activation antigen, increasing in both brain-invading CD4+ and CD4− T cells	2018