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. 2021 Jan 19;11:21. doi: 10.1186/s13578-021-00531-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Tumorigenicity and differentiation potential of neural stem cell NE-4C. a Tumor formation by NE-4C in nude mice. b Tissue differentiation in NE-4C xenograft tumors examined by histology. A partial overview of a section with HE staining and particular tissue types in the section are shown. Original objective magnifications for sections: 4× for overview, 40× for specific tissues. c–e Differential expression of genes representing neural stemness (c), neuronal differentiation (d), and mesendodermal tissue differentiation (e) in NE-4C cells and tumor, as detected with RT-qPCR. Significance of expression change was calculated based on experiments in triplicate using two-tailed Student’s t-test. Data are shown as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. NS: not significant. f IHC detection of cell/tissue markers in tumor sections. Below the marker panels are corresponding sections stained with HE. Objective magnification: 20×; insets: 40×