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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Nature. 2020 Jun 3;584(7822):646–651. doi: 10.1038/s41586-020-2357-y

Figure 4: Channel assembly of hsPANX1.

Figure 4:

a, An overview of the intersubunit interfaces at the ECD, TMD and ICD using wt-hsPANX1 model. b, The intersubunit interface at the ECD, viewed from the intracellular side. The extracellular entrance is formed by W74 on the EH1 helix. c, The ECD intersubunit interface viewed parallel to the membrane. R75 forms a cation-π interaction and a salt bridge with adjacent W74 and D81, respectively; F67 is inserted in a hydrophobic pocket in the adjacent subunit. Part of the EH1 in is transparent. d, The intersubunit interface of the TMD between NTH and the adjacent S1 and S2, viewed from the intracellular side. Only the TMD helices are shown. The gap between adjacent TMDs is filled with lipids. e, The TMD interface viewed parallel to the membrane. f, The intersubunit interface at the lower part of the ICD between the IH1 and IH2 helices and the adjacent IH6 and IH7 helices. A crevice in the upper part of the ICD forms a tunnel that connects to the main pore.