. Author manuscript; available in PMC: 2021 Dec 31.

Published in final edited form as: IEEE Trans Biomed Circuits Syst. 2020 Dec 31;14(6):1207–1217. doi: 10.1109/TBCAS.2020.3037452

Table II:

Benchmarking of State-of-Art Multifunctional Neural Interface SoC

Publication	2017 [11]	2019 [14]	2018 [24]	2018 [19]	2019 [25]	This work
Technology	0.13-μm	0.18-μm+FPGA	0.18-μm	0.13-μm+MCU	0.18-μm+COTS	0.35-μm
No. interfacing modalities	2	2	2	2	3	3

No. recording channels	64	128	N/A	10	2	16
Input-referred noise / bandwidth	1.13 μVrms / (0.1–500 Hz)	1.6 μVrms /	N/A	3.2 μVrms / (10 Hz-7 kHz)	1.2 μVrms/ (25.4 Hz-25.6 kHz)	3.46 μVrms / (1 Hz-50 kHz)
Channel gain / bandwidth	/ (0.01–500 Hz)	/ Up to 500 Hz	N/A	46 dB / (0.5 Hz-7 kHz)	27 dB / Up to 187.5 Hz	55–70 dB / (1–100) Hz −10 kHz

Electrical stimulation channels	64	128	4	N/A	1	8
Electrical stimulation current	10–1350 μA	20 μA-5 mA	22 μA-5 mA	N/A	0–510 μA	25–775 μA
Charge balancing	Yes	Yes	Yes	N/A	Yes	Yes

Optical stimulation channels	N/A	N/A	1	4	1	16
Optical stimulation current	N/A	N/A	22 μA-5 mA	0–35 mA	Up to 120 mA	0.8–24.8 mA
Light intensity	N/A	N/A	Up to 23 mW/mm²	N/A	Up to 50 mW/mm²	Up to 31.5 mW/mm²

Power transmission	Inductive link	Battery	Ultrasound	Battery	Battery	Inductive link
Downlink data	ASK / Inductive link	BLE	ASK / Ultrasound link	Nordic TRx	OOK TRx	OOK-PPM / Inductive link
Uplink data	UWB	BLE	N/A	Nordic TRx	OOK TRx	OOK / 434 MHz RF