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. Author manuscript; available in PMC: 2021 Feb 7.
Published in final edited form as: J Org Chem. 2019 Dec 9;85(3):1331–1339. doi: 10.1021/acs.joc.9b02631

Table 1.

MIC values of teixobactin and teixobactin analogues (μg/mL).

Staphylococcus aureus ATCC 29213 Staphylococcus epidermidis ATCC 14990 Bacillus subtilis ATCC 6051 Escherichia coli ATCC 10798
Arg10-teixobactin (1a) 2 1 2 >32
d-aza-Thr8,Arg10-teixobactin (2a) 1 0.5 1 >32
d-allo-aza-Thr8,Arg10-teixobactin (2b) >32 >32 >32 >32
l-aza-Thr8,Arg10-teixobactin (2c) >32 >32 >32 >32
l-allo-aza-Thr8,Arg10-teixobactin (2d) >32 >32 >32 >32
teixobactin 0.25 0.25 0.25–0.5 >32
vancomycin 0.25 0.25 0.5 >32