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. Author manuscript; available in PMC: 2021 Feb 7.
Published in final edited form as: J Org Chem. 2019 Dec 9;85(3):1331–1339. doi: 10.1021/acs.joc.9b02631

Table 3.

MIC values of ring-expanded teixobactin analogues (μg/mL).

Staphylococcus aureus ATCC 29213 Staphylococcus epidermidis ATCC 14990 Bacillus subtilis ATCC 6051 Escherichia coli ATCC 10798
Arg10-teixobactin (1a) 2 1 2 >32
β3h-Ala9,Arg10-teixobactin (4) 32 4 8 >32
β3h-Arg10-teixobactin (5) 8 1 2 >32
Arg10,β3h-Ile11-teixobactin (6) 4 2 4 >32
β3h-Ala9, β3h-Arg 10-teixobactin (7) >32 >32 >32 >32
β3h-Ala9,Arg10,β3h-Ile11-teixobactin (8) 32 16 16 >32
β3h-Arg10,β3h-Ile11-teixobactin (9) 4 1 4 >32
β3h-Ala9,β3h-Arg10,β3h-Ile11-teixobactin (10) 16 2 4 >32
teixobactin 0.25 0.25 0.25–0.5 >32
vancomycin 0.25 0.25 0.5 >32