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. 2021 Jan 19;16:64. doi: 10.1186/s13018-021-02208-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Upregulated expression of MMP8 and MMP9 in the knee joint cartilage of diabetic OA rats. a After 4 weeks of a high-fat diet, blood glucose values of the model (STZ) and control (NC) rats were monitored at 1 and 2 weeks after modeling. b The body weights of rats in each group were recorded after 1–6 weeks of OA induction. c OGTT results of STZ and NC rats. d Safranin O-Fast green staining was used to detect articular cartilage lesions in diabetic OA and NC rats. OARSI scores (e) and articular cartilage thickness (f) in diabetic OA and NC rats. g–i IHC showing the expression levels of MMP8 and MMP9 in the joint tissues of diabetic OA and NC rats. Image-Pro Plus was used to quantify the expression. Diabetic OA diabetic osteoarthritis, T2D high-fat diet combined with STZ, NC normal control, OGTT oral glucose tolerance test, MMP matrix metalloproteinase. **p < 0.01