TABLE 4.
Mediation analysis findings in MDD and HC groups
| Effect | Path coefficient (p‐value) | |
|---|---|---|
| MDD | HC | |
| Direct | ||
| EP→ER | −.604 (.001) | −.165 (.308) |
| ER→SEE | .305 (.318) | −.126 (.429) |
| EP→SEE | −.198 (.504) | −.140 (.484) |
| Indirect | ||
| (β EP→ER * β ER→SEE) | −.193 (.468) | .022 (.619) |
| Total | ||
| [(β EP→SEE) + (β EP→ER * β ER→SEE)] | −.391 (.002) | −.119 (.553) |
Note: Emotion processing (EP) as exogenous variable is indicated by the amplitude of low frequency fluctuations (ALFF) of response seed (right amygdala), emotion regulation (ER) as mediator variable is indicated by the ALFF of initiation seed (left dorsolateral prefrontal cortex) and regulatory behavior as endogenous variable is indicated by the Skalen zum Erleben von Emotionen (SEE) scores. Direct, indirect, and total effects are shown for major depressive disorder (MDD) and healthy control (HC) groups.