TABLE 5.

Correlation of depression severity (Hamilton Rating Depression Scale‐17) with whole‐brain functional connectivity of emotion processing and regulation seeds in MDD group (p < .003, FWE‐ and Bonferroni‐corrected)

	Step	Seed	P FWE	Cluster size	Target	Contrast	MNI (X,Y,Z)
Emotion processing	Visual	MFG, LG, CUN	n/s	–	–	–	–
	Auditory	IC, STG, CG	n/s	–	–	–	–
	Attention	FG, IC, CG, TH	.0001	361	R IPL	Negative correlation	34, −60, 30
	Appraisal	MFG, PCC	n/s	–	–	–	–
	Response	MTG, AMY, FuG	n/s	–	–	–	–
Emotion regulation	Evaluation	VLPFC	n/s	–	–	–	–
	Initiation	DLPFC	.003	188	R VLPFC	Negative correlation	−46, 50, −8
	Execution	AG, (pre) SMA	n/s	–	–	–	–

Abbreviations: AG, angular gyrus; AMY, amygdala; CG, cingulate gyrus; CUN, cuneus; DLPFC, dorsolateral prefrontal cortex; FG, frontal gyrus; FuG, fusiform gyrus; HC, healthy control; IC, insular cortex; IPL, inferior parietal lobule; LG, lingual gyrus; MDD, major depressive disorder; MFG, middle frontal gyrus; MPFC, middle prefrontal cortex; MTG, middle temporal gyrus; PCC, posterior cingulate cortex; pre‐SMA, pre‐supplementary motor area and SMA; STG, superior temporal gyrus; TH, thalamus; VLPFC, ventrolateral prefrontal cortex.