FIGURE 5.

Receiver operating characteristic (ROC) curve for uncorrected VBM changes and diffusion index alterations as indicators An optimal diffusion metric cutoff value of the VBM changes in the MFG/PreCG and AD values in the bilateral MCP and their combination was determined at a sensitivity of 77.1, 65.7, 94.3, and 77.1% and a specificity of 75.9, 69.0, 48.3, and 82.8%, respectively. The areas under the curve (AUCs) for the ROC curve were 0.780, 0.673, 0.693, and 0.851 (95% confidence intervals from 0.666 to 0.895, 0.540 to 0.806, 0.557 to 0.828, and 0.757 to 0.945, respectively). The PPV and NPV for the gray matter change of the MFG/PreCG and the white matter (WM) integrity change in the bilateral MCP and the combination of them were 72.6 and 80.0%, 63.7 and 70.8%, 60.2 and 91.1%, and 78.8 and 81.9% separately. AD, axial diffusivity; MCP, middle cerebellar peduncle; MFG, middle frontal gyrus; PreCG, precentral gyrus