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. Author manuscript; available in PMC: 2021 Dec 18.
Published in final edited form as: ACS Chem Biol. 2020 Nov 21;15(12):3099–3105. doi: 10.1021/acschembio.0c00755

Figure 1. UPRT-dependent metabolic labeling of RNA.

Figure 1.

a. Schematic of (−) TgUPRT versus TgUPRT expressing cell that enable cell-specific metabolic labeling of RNA. b. Crystal structure of TgUPRT enzyme (PDB 1bd4). c. Close-up view of TgUPRT active site. Positions chosen for mutagenesis are labeled.