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. 2021 Jan 15;14:455–467. doi: 10.2147/OTT.S286751

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© 2021 Rodrigues-Junior et al.

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Overexpression of miR-1252-5p regulates negatively HPSE expression and activity in MM cells. The MM cells (A; U266 and B; RPMI-8226) were transfected with synthetic miR-1252-5p mimic and with a miRNA mimic negative control (miRctrl). The levels of HPSE mRNA (C; U266 and D; RPMI-8226) and protein (E) were checked by RT-qPCR and flow cytometry, respectively. HPSE enzymatic activity was measured by an ELISA-like method using HS biotinylated (F; U266 and G; RPMI-8226). The standard deviation observed in three independent experiments was indicated. Asterisks denote significance as determined by Mann–Whitney test; *p < 0.05, **p < 0.01, ***p < 0.0001.