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. 2021 Jan 15;14:455–467. doi: 10.2147/OTT.S286751

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© 2021 Rodrigues-Junior et al.

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Engineered EVs carrying miR-1252-5p sensitizes MM cells to BTZ. (A) Experimental strategy of miR-1252-5p delivery by HEK293T EVs. (B) Relative levels of miR-1252-5p in untreated HEK293T VSF, incubated or electroporated with 30 pmol of synthetic miR-1252-5p, and treated with RNase was measured by RT-qPCR. (C) RPMI-8226 WT cells were treated with HEK293T VSF, eVSFctrl, or eVSF, on the presence of 5.0 nM BTZ and cell viability was quantified using PrestoBlue assay. Asterisks denote significance as determined by one-way ANOVA, multiple comparisons followed by Bonferroni test (post-test) (*p < 0.0001).