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. Author manuscript; available in PMC: 2021 Jan 19.
Published in final edited form as: Cancer Immunol Res. 2018 Nov 5;7(1):100–112. doi: 10.1158/2326-6066.CIR-18-0307

Figure 4: NKG2D-ligand expression and soluble ligands.

Figure 4:

A) Surface NKG2D ligand detection in AML blasts (7 AML patients) and MM cells (3 MM patients) in bone marrow aspirates (BMA) at baseline measured by flow cytometry (SFI>1 indicates ligand expression exceeding isotype). AML blasts: live/CD45dim cells expressing patient-specific AML markers including CD117, CD123, CD33, and HLA-DR. MM cells: live/CD138+CD38+ cells. B) Detection of soluble MICA and MICB in patient plasma at baseline using ELISA. Plasma of Patient 3 (MM) was separately spiked with soluble MICA and MICB as an internal positive control. ND: not detectable.