Table 1.

Mutations Identified in Multiple Individuals

Mutationa	Individualsb	Group	Typec	Region	Fraction of cVDPVd
A481G	72	Gatekeeper	Noncoding	5′ UTR	1
U2909C	25	Gatekeeper	NS	VP1	0.75
A2908G	19	Gatekeeper	NS	VP1	0.03
U398C	16	Gatekeeper	Noncoding	5′ UTR	0.94
A2074G	12	Capsid	NS	VP3	0.01
A2992G	11	Capsid	NS	VP1	0.03
A2986G	10	Antigenic	NS	VP1	0.01
G6084U	10	3D	S	3D	0.03
A1997G	8	Antigenic	NS	VP3	0.05
U2909A	8	Gatekeeper	NS	VP1	0.03
U882C	8	Capsid	S	VP4	0.02
G2782A	7	Antigenic	NS	VP1	0.01
G491A	7	Noncoding	Noncoding	5′ UTR	0.14
G619U	7	Noncoding	Noncoding	5′ UTR	0
C2609U	6	Capsid	NS	VP1	0.01
C2783A	5	Antigenic	NS	VP1	0
U4374C	5	2C	S	2C	0.55
A3490G	4	2A	NS	2A	0.02
C2291U	4	Capsid	NS	VP3	0.01
C2580U	4	Capsid	S	VP1	0.1
G1282A	4	Capsid	NS	VP2	0
U1641C	4	Capsid	S	VP2	0.68
U5811A	4	3C	S	3C	0.14
U6693A	4	3D	S	3D	0.31

^aMutation presented as base in OPV2, position in OPV2 reference genome, and base in samples.

^bNumber of individuals with each mutation present at a frequency of 5% or greater. The total number of individuals analyzed is 83.

^cNonsynonymous (NS) or synonymous (S) mutations relative to the OPV2 reference genome.

^dFraction of cVDPV genomes with each mutation.