Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 15;14:153–163. doi: 10.2147/DMSO.S285179

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Wang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

miR-129-3p directly regulates MCU expression in glucose fluctuation-exposed hippocampal neuronal neuronal cells. Rat primary hippocampal neuronal cells were exposed to normal glucose (control, CT), low glucose (LG), high glucose (HG) and glucose fluctuation (GV) conditions. (A and B) Protein levels of MCU. (C) mRNA levels of miR-129-3p. (D) Predicted mi R-129-3p target sequence in the MCU-3 ‘ UTR. Target sequences of MCU-3 ‘UTR were mutated. (E) Luciferase assay of cells transfected with MCU-WT or MCU-MUT reporter together with miR-129-3p mimic or miR-NC. (F) mRNA levels of MCU in cells transfected with miR-129-3p inhibitor or mimics and miR-NC. Data are presented as the means ± SD; ** p< 0.01; (n = 5).