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Schematic diagram of adverse effect of hyper-O-GlcNAcylation in the progression of bladder cancer. Up-regulation of O-GlcNAcylation level with PuGNAc and GlcNAc treatment promotes the expression and stability of NUSAP1 protein, and accelerates the proliferation and tumorigenesis and represses the apoptosis of bladder cancer cells.
