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. 2021 Jan 19;16(1):e0245581. doi: 10.1371/journal.pone.0245581

Fig 4. Double contrast barium enema and grossed appearance of the colon and rectum post and pre-treatment in rats.

Fig 4

A) Apparently normal colon lesion showing free uptake of the barium. B and C) Tumour involvement was evident by diffuse uptake of the barium at the anterior portion of the colon and little uptake at the mid to caudal portion. This signifies tumour involvement. D) Disarrayed uptake of the barium post-aspirin plus FOLFOX treatment. E, Grossed section of apparently normal colorectal lesions with arrows pointing to areas occluded by faecal materials. F) Tumour-bearing colorectal lesions Pre aspirin plus FOLFOX treatment with arrows showing areas with tumour involvement and total absent of faecal material. G) Tumour-bearing colorectal lesion post-treatment with aspirin plus FOLFOX in sequence showing apparently normal areas. H) Tumour-bearing colorectal lesion post-concurrent treatment with aspirin plus FOLFOX showing irregular distorted architecture of the colon and rectum with haemorrhagic areas.