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. 2021 Jan 19;16(1):e0245581. doi: 10.1371/journal.pone.0245581

Fig 7. Prognostic significance of p53, Bcl-2 and Annexin V in colorectal cancer cells post-treatment with FOLFOX with or without aspirin in rat (scale bar = 50 μm for H&E and scale bar = 100 μm for IHC).

Fig 7

A) Show positive expression of p53 and Bcl-2 and negative expression of Annexin V in normal colorectal sections. B to F), Show positive expression of p53, Bcl-2 and Annexin V in colorectal cancer sections pre and post-treatment with 25 mg/kg aspirin, aspirin plus FOLFOX in sequence, aspirin plus FOLFOX concurrent, and folinic acid treatment. G to I) Quantitative analysis of the p53, Bcl-2 and Annexin V from the rats showing expression pattern typified in dot plot post and pre-treatment with aspirin and aspirin plus FOLFOX in various combinations.