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. 2021 Jan 19;16(1):e0245581. doi: 10.1371/journal.pone.0245581

Fig 9. Prognostic significance of PD-L1, DARC and DNA mismatch repair protein PMS2 in NMU-induced CRC in rat and treated with aspirin, and aspirin plus FOLOFOX in varous combinations (scale bar = 50 μm for H&E and scale bar = 100 μm for IHC).

Fig 9

A) Show negative expression of PD-L1, DARC and PMS2 in sections from non CRC-bearing rats. B) Show strong positive expression of PMS2 and negative expression of PD-L1 in the sections from the untreated CRC-bearing rats. C) CRC sections from the rat treated with 25 mg/kg aspirin showing negative expression of PD-L1 and mild expression of PMS2. D) Sections from aspirin plus FOLFOX sequential treated cells showing strongly positive expression of PD-L1 and PMS2 with mild expression of DARC. E) CRC sections treated with concurrent dose of aspirin plus FOLFOX showing mild expression of PD-L1 and DARC and strongly positive expression of PMS2. F) Sections treated with folinic acid showing focal expression of PD-L1, strong positive expression of DARC and mild expression of PMS2. G to I) Quantitative analysis of the PD-L1, DARC and PMS2 from the study showing expression pattern typified in dot plot post and pre-treatment with aspirin and aspirin plus FOLFOX in various combinations.