Table 5. Biochemical findings of various group of rats induced with colorectal cancer and treated with Aspirin plus FOLFOX chemotherapy in various combinations.
| Serum urea and electrolyte | Liver function test | |||||||
|---|---|---|---|---|---|---|---|---|
| Treatments | Urea (mmol/L) | Potassium(mmol/L) | Sodium (mmol/L) | Chloride (mmol/L) | HCO3-* (mmol/L) | AST** (UI/L) | ALT**** (UI/L) | ALP**** (UI/L) |
| Normal (CRC free rats) | 3.4±1.6 | 5.7±.9 | 136.3±1.5 | 101.6±2.8 | 18.0±3.6 | 146.0±26.9 | 62.0±14.0 | 845.0±208.9 |
| CRC- induced | 5.3±.3 | 4.9±.3 | 132.5±.7 | 94.5±.7 | 9.5±6.4 | 190.0±91.9 | 33.0±12.7 | 648.5±55.8 |
| p valuea | 0.0075 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0260 | 0.0001 | 0.0001 |
| Aspirin alone | 3.3±.8 | 5.7±1.2 | 133.8±4.8 | 98.5±4.5 | 31.0±11.8 | 145.5±63.1 | 61.8±22.9 | 725.5±575.1 |
| p-valuea | 0.9514 | 1.0000 | 0.0165 | 0.0053 | 0.0001 | 0.9711 | 0.9704 | 0.3337 |
| Aspirin + FOLFOX (Sequentially) | 3.1±1.9 | 7.2±3.3 | 122.0±15.5 | 87.0±11.3 | 18.5±9.2 | 107.5± 23.3 | 38.0±8.5 | 755.5±400.9 |
| p-valuea | 0.5488 | 0.0332 | 0.0001 | 0.0001 | 0.8013 | 0.0001 | 0.0001 | 0.3272 |
| Aspirin + FOLFOX (Concurrently) | 2.3±1.9 | 6.5±2.9 | 127.0±7.9 | 89.0±8.2 | 23.4±4.6 | 148.4±41.4 | 40.4±12.5 | 329.0±61.9 |
| p-valuea | 0.0316 | 0.1940 | 0.0001 | 0.0001 | 0.0001 | 0.8090 | 0.0001 | 0.0001 |
| 5-FU alone | 6.7±4.7 | 7.9±3.5 | 121.5±10.6 | 85.0±7.0 | 23.5±3.5 | 273.5±174.6 | 77.0±35.4 | 296.0±18.4 |
| p value | 0.0017 | 0.0038 | 0.0001 | 0.0001 | 0.0001 | 0.0007 | 0.0546 | 0.0001 |
Values are presented as mean±SD. Each parameter of the treatment type was compared with the cancer induced group.
aThe result is significant when p <0.05.
*HCO3- (Bicarbonate).
** AST (Aspartate aminotransferase).
*** ALT (Alanine aminotransferase).
****ALP (Alkaline phosphatase).