Table 1.
Allosteric Network Analysis between Switch I and II and C-Terminal Residues in K-Ras4A and K-Ras4B (151, 153, 165, and 166)a
| 151 |
153 |
165 |
166 |
|||||
|---|---|---|---|---|---|---|---|---|
| residue | K-Ras4A-GDP | K-Ras4B-GDP | K-Ras4A-GDP | K-Ras4B-GDP | K-Ras4A-GDP | K-Ras4B-GDP | K-Ras4A-GDP | K-Ras4B-GDP |
| 25 | 237(1) | 218(3) | 252(1) | 167(2) | 479(44) | 406(36) | 501(80) | 425(39) |
| 26 | 236(1) | 231(6) | 251(1) | 180(4) | 478(44) | 419(29) | 500(80) | 438(28) |
| 27 | 255(2) | 250(9) | 270(2) | 199(6) | 497(51) | 438(34) | 519(90) | 457(31) |
| 28 | 267(2) | 276(11) | 282(2) | 225(7) | 509(51) | 464(37) | 531(90) | 483(33) |
| 29 | 280(4) | 311(14) | 295(4) | 260(8) | 522(80) | 499(40) | 544(143) | 518(35) |
| 30 | 288(6) | 366(14) | 303(6) | 315(8) | 530(104) | 554(40) | 552(182) | 573(35) |
| 31 | 296(16) | 396(18) | 311(16) | 345(9) | 538(167) | 584(43) | 560(280) | 603(37) |
| 32 | 298(17) | 409(18) | 313(17) | 358(9) | 540(178) | 597(48) | 562(296) | 616(39) |
| 33 | 323(27) | 448(18) | 338(27) | 397(9) | 565(249) | 630(35) | 587(411) | 625(3) |
| 34 | 466(27) | 479(22) | 481(27) | 428(10) | 597(89) | 606(6) | 619(166) | 624(20) |
| 35 | 500(27) | 522(40) | 515(27) | 471(19) | 587(89) | 563(3) | 609(166) | 581(12) |
| 36 | 505(4) | 517(25) | 520(4) | 466(12) | 529(89) | 561(17) | 551(166) | 556(3) |
| 37 | 484(2) | 465(2) | 499(2) | 414(2) | 508(60) | 491(16) | 530(110) | 486(3) |
| 38 | 449(2) | 437(2) | 464(2) | 386(2) | 473(60) | 463(16) | 495(110) | 458(3) |
| 39 | 424(1) | 410(1) | 439(1) | 359(1) | 448(36) | 440(10) | 470(64) | 435(2) |
| 40 | 363(1) | 355(1) | 378(1) | 304(1) | 387(19) | 413(44) | 409(35) | 428(24) |
| 57 | 317(4) | 339(2) | 332(4) | 325(6) | 403(30) | 420(9) | 407(5) | 419(3) |
| 58 | 331(1) | 378(4) | 346(1) | 366(15) | 392(11) | 379(3) | 413(22) | 397(8) |
| 59 | 410(1) | 444(4) | 425(1) | 432(15) | 471(11) | 445(3) | 492(22) | 463(8) |
| 60 | 504(1) | 485(4) | 519(1) | 473(15) | 565(11) | 486(3) | 586(22) | 504(8) |
| 61 | 532(1) | 508(4) | 547(1) | 496(15) | 582(14) | 509(17) | 591(22) | 525(142) |
| 62 | 562(1) | 527(4) | 577(1) | 515(15) | 552(12) | 504(143) | 561(22) | 506(94) |
| 63 | 593(1) | 534(12) | 608(1) | 522(23) | 553(16) | 481(64) | 562(24) | 483(41) |
| 64 | 628(1) | 530(10) | 643(1) | 518(18) | 553(30) | 477(59) | 562(31) | 479(37) |
| 65 | 647(30) | 517(6) | 607(33) | 505(16) | 494(16) | 464(45) | 503(17) | 466(30) |
| 66 | 587(24) | 521(13) | 547(27) | 509(25) | 434(11) | 465(86) | 443(14) | 467(65) |
| 67 | 578(18) | 516(6) | 538(19) | 504(16) | 425(9) | 455(27) | 434(13) | 457(20) |
| 68 | 582(37) | 499(4) | 542(41) | 487(15) | 429(12) | 446(18) | 438(22) | 448(14) |
| 69 | 573(22) | 514(4) | 533(24) | 502(15) | 420(10) | 447(36) | 429(14) | 449(30) |
| 70 | 553(12) | 534(13) | 513(13) | 522(41) | 400(5) | 433(14) | 409(11) | 435(12) |
| 71 | 542(21) | 531(14) | 502(23) | 510(31) | 389(6) | 414(6) | 398(15) | 416(6) |
| 72 | 538(43) | 539(37) | 498(46) | 509(36) | 385(10) | 413(12) | 394(20) | 415(12) |
| 73 | 510(21) | 516(19) | 470(23) | 482(19) | 357(6) | 386(6) | 366(15) | 388(6) |
| 74 | 480(11) | 484(11) | 440(12) | 450(11) | 327(4) | 354(4) | 336(10) | 356(4) |
| 75 | 436(10) | 455(8) | 396(11) | 421(8) | 283(2) | 325(2) | 292(5) | 327(2) |
a
The length of the shortest path between the residues is noted, followed by the number of suboptimal paths identified between the two residues in parentheses. Highlighted in bold are those residues for which the shortest path length is shorter in K-Ras4A than in K-Ras4B and in which the number of suboptimal paths is greater in K-Ras4A than in K-Ras4B. Residues in the switch II region are denoted in bold.