Table 1.

Studies assessing uptake of COS in RCTs and SRs

COS disease name	Scope of uptake study	Period assessed for uptake of COS	No. RCTs assessed	% RCTs measuring each COS outcome	% RCTs measuring full COS
Psoriatic arthritis	Psoriatic arthritisA4	2006 – 2010	17	77, 71, 59, 53, 47, 47	24
	Psoriatic arthritisA13	2010 – 2015	22	100, 95, 91, 86, 82, 77	59
Knee, hip, and hand	Trapeziometacarpal osteoarthritisA5	- 2010	316a	96, 94, 67, 59, 4b	-
osteoarthritis	Total knee anthroplastyA16	- 2014	30	93, 27, 10c	7
	Hip or knee osteoarthritisA23	1997 – 2017	382	95, 86, 75, 48	45
	OsteoarthritisA25	2012 – 2017	334	97, 84, 17, 30	14
Rheumatoid arthritis	DMARD therapy for rheumatoid arthritisA1d	1986 – 1990	32	100, 91, 91, 91, 91, 73, 73, 64, 55, 55 100, 91, 91, 91, 73, 55, 27	- -
	Rheumatoid arthritisA2	2005 – 2007	50e	-	82
	Rheumatoid arthritisA6	- 2009	350		60-70f
	Rheumatoid arthritisA17	2002 – 2016	143	-	81
	Rheumatoid arthritisA22	2009 - 2019	197	-	Just over 80
Ankylosing spondylitis	Ankylosing spondylitis/axial spondyloarthritisA7	- 2013	99	92, 84, 77, 51, 46, 44g 97, 97, 92, 84, 82, 79, 68, 63, 16h	20
Acute and chronic	Acute goutA8	- 2011	77i	99, 57, 51, 32, 5	-
gout	Acute and chronic goutA11	- 2013	38j 30j	87, 79, 71, 29, 8, 80, 73, 70, 10, 7, 3, 0, 0, 0	5 0
Chronic pain	Cognitive and/or behavioral treatmentA3	- 2010	60	94, 83, 12 domains >40, 5 domains 0	-
	Acceptance and Commitment TherapyA9	1999 - 2014	10	90, 90, 80, 70, 10, 10	-
	Burning mouth syndromeA21	1994 – 2017	36	100, 97, 78, 33, 28, 22	11
	Opioids for chronic non-cancer painA10	- 2012	156	99, 94, 76, 46, 43, 31, 28, 19, 7	-
Pediatric acute and chronic pain	Postoperative pain managementA18	- 2017	337	93, 83, 21, 16, 15, 15	-
Fall injury	Fall prevention in older peopleA14	2005 – 2015	34	94, 47, 24, 24, 21	3
Spinal cord injury	Anticholinergic therapy for neurogenic bladder in SCIA15	1946 – 2015	14	3	3
Hip fracture	Hip fractureA24	1997 – 2018	311	47, 46, 41, 37, 29	12
Peripheral neuropathy	Multifocal motor neuropathyA12	1995 – 2014	8	100, 100, 13	13
Eczema	Atopic eczema treatmentsA26k	2005 – 2018	177	-	25%l 33%m
			No. SRs assessed	% SRs measuring each COS outcome	% SRs measuring full COS
Chronic pain	Neuropathic pain conditionsA19	- 2015	90	94, 84, 53, 50, 49, 29	10
Pediatric acute and chronic pain	Postoperative painA20	- 2017	48	88, 75, 29, 21, 19, 15	-

^A1-A26 corresponds to uptake study listed in Supplementary File C.

^aIncludes RCTs and observational studies.

^bAssessed all 4 inner core domains plus 1 middle core domain.

^cUptake of 1 outcome not reported individually but included in full uptake assessment.

^dStudy included 2 COS.

^eExcluded trials from assessment if they did not report at least 1 patient reported outcome (PRO).

^fIn 2009.

^gSMARD.

^hDC-ART.

ⁱExcluded trials from assessment if they did not report at least 1 core outcome.

^jIncludes quasi-RCTs (3 acute, 2 chronic).

^k3 domains assessed as 1 domain not defined at time of review.

^lAverage from 2005 to 2018.

^mIn 2018.